I hadn’t used these external devices for a long time. Occasionally, I took them out for a test flight to see if they still worked. I reinstalled the Xsaitekpanels (lin+win+mac+32/64) Plugin mentioned before. After launching X-Plane, I got an error saying the Plugin’s Mac.xpl had a security issue.

So, I checked online articles and found this one – Mac.xpl Not Starting

It turns out that you just need to allow Mac.xpl in the system security settings.